Asymmetric syntheses of the 1-hydroxymethyl-2-hydroxy substituted pyrrolizidines (−)-macronecine, (−)-petasinecine, (−)-1- epi -macronecine, (+)-1- epi -petasinecine and (+)-2- epi -rosmarinecine
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منابع مشابه
Asymmetric syntheses of 1-deoxy-6,8a-di-epi-castanospermine and 1-deoxy-6-epi-castanospermine.
Asymmetric syntheses of both 1-deoxy-6,8a-di-epi-castanospermine and 1-deoxy-6-epi-castanospermine, polyhydroxylated indolizidine alkaloids that act as selective glycosidase inhibitors, have been accomplished in seven steps. The key feature of our unique syntheses includes the stereoselective introduction of the C-3 and C-4 hydroxyl groups utilizing the aza-Claisen rearrangement-induced ring ex...
متن کاملTHE SYNTHESES OF 1- [[2- AMINO -1 - (HYDROXYMETHYL) ETHOXY] METHYL] URACIL AND 1, 3-BIS (2- HALOETHOXYMETHYL) PYRIMIDINE
The syntheses of the title compounds are described. 1- [[2- Amino -1 - (hydroxymethyl) ethoxy] methyl] uracil exhibitslittleactivity against herpesviruses (HSV) in vivo
متن کاملAsymmetric total synthesis of 1-deoxy-7,8-di-epi-castanospermine.
An efficient, stereocontrolled synthesis of (6S,7S,8S,8aR)-6,7,8-trihydroxyindolizidine (alias 1-deoxy-7,8-di-epi-castanospermine) (14) has been developed, which exploits an asymmetric vinylogous Mukaiyama aldol reaction (VMAR) between N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsilyloxy)pyrrole (1) and 2,3-O-isopropylidene-D-glyceraldehyde (2) to construct the initial pyrrolidine building blo...
متن کاملApplications of Epi-Retractable and Co-Epi-Retractable Modules
A module M is called epi-retractable if every submodule of M is a homomorphic image of M. Dually, a module M is called co-epi-retractable if it contains a copy of each of its factor modules. In special case, a ring R is called co-pli (resp. co-pri) if RR (resp. RR) is co-epi-retractable. It is proved that if R is a left principal right duo ring, then every left ideal of R is an epi-retractable ...
متن کاملErratum: Applications of epi-retractable and co-epi-retractable modules
In this errata, we reconsider and modify two propositions and their corollaries which were written on epi-retractable and co-epi-retractable modules.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2016
ISSN: 0040-4020
DOI: 10.1016/j.tet.2016.09.047